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KMID : 0364519960080020227
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Dong-A Journal Medicine
1996 Volume.8 No. 2 p.227 ~ p.234
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Immunohistochemical Expression of nm23 and p53 Protein in Colorectal Adenoma
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Abstract
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The product of nm23 gene has been proposed as a candidate tumor metastasis suppressor protein. A strong association has been observed between reduced expression of nm23 gene and acquisition of metastatic behaviors in some tumor cells including
breast
cancer and melanoma, but the exact role of nm23 in colorectal neoplasia is unclear. This study was aimed to evaluate the expression pattern of nm23 protein in early stage of colorectal carcinogenesis in relation to the degree of dysplasia and to
elucidate a relationship with a well-known tumor suppressor gene, p53 We performed an immunohistochemial study on formalin-fixed, paraffin-embedded sections from 30 patients of colorectal adenoma. The expression of nm23 protein in adenoma was
slightly
higher than in normal colon tissue and showed to be more increased in high grade dysplasia than in low grade dysplasia, although there were no statistically significant differences. But the expression of p53 protein in adenoma was significantly
higher
than normal colon tissue and showed to be significantly more increased in high grade dysplasia than in low grade dysplasia. In addition all cases of adenomas showing the simultaneous positive reaction to nm23 and p53 protein were high grade
dysplasia.
In conclusion , it was suggested that the expression of nm23 protein in early stage of colorectal carcinogenesis might be related to p53 protein expression during the progression from late adenoma to carcinoma, although the expression of nm23
protein
alone in adenoma showed no significant role.
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